Development of Solid-self Micro Emulsifying Formulation to Improve Oral Bioavailability

The improvement of bio-availability of drugs presents one of the greatest challenges in drug formulations. One of the most popular and commercially viable formulation approaches for this challenge is self-micro emulsifying drug delivery systems (SMEDDS). 1 SMEDDS are defined as isotropic mixtures of natural or synthetic oils, solid or liquid surfactants, or alternatively, one or more hydrophilic solvents and cosolvents/surfactants that have a unique ability of forming fine oil-in-water (o/w) microemulsion upon mild agitation followed by dilution in aqueous media, such as GI fluids. 2 Liquid SEDDS and SMEDDS are inconvenient to use and incompatibility problems with the shells of the soft gelatin are frequent. Solid SMEDDS have recently been described and they overcome the disadvantages of liquid SMEDDS as well as exhibited more commercial potential and patient acceptability. 3, 4